119 - Standardisation of HbA1c Measurements:practical consequences and course of activation
Autor(s): A. Mosca
Issue: RIMeL - IJLaM, Vol. 4, N. 3-S1, 2008 (MAF Servizi srl ed.)
Page(s): 119
The measurement of hemoglobin A1c has been the goldstandard measurement of chronic glycemia for over two decades. Since elevated HbA1c values increase the likelihood of the microvascular and perhaps macrovascular complications of diabetes, clinicians have used HbA1c test results to guide treatment decisions, and the assay has become the cornerstone for the assessment of diabetes care. To achieve a more uniform standardization of HbA1cmeasurements, the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) developed a new reference method that specifically measures the concentration of only one molecular species of HbA1c. Results by the new reference method have also been compared with the results obtained by current methodologies, and the relation between the assays can be expressed by simple regression equations (“master equations”). A network of IFCC Reference Laboratories is now in place, and it has been proved that the Reference system is robust and stable over time. ...